Harnessing organs-on-a-chip to model tissue regeneration

Daniel Naveed Tavakol; Sharon Fleischer; Gordana Vunjak-Novakovic

doi:10.1016/j.stem.2021.05.008

Harnessing organs-on-a-chip to model tissue regeneration

Cell Stem Cell. 2021 Jun 3;28(6):993-1015. doi: 10.1016/j.stem.2021.05.008.

Authors

Daniel Naveed Tavakol¹, Sharon Fleischer¹, Gordana Vunjak-Novakovic²

Affiliations

¹ Department of Biomedical Engineering, Columbia University, New York, NY.
² Department of Biomedical Engineering, Columbia University, New York, NY; Department of Medicine, Columbia University, New York, NY. Electronic address: gv2131@columbia.edu.

Abstract

Tissue engineering has markedly matured since its early beginnings in the 1980s. In addition to the original goal to regenerate damaged organs, the field has started to explore modeling of human physiology "in a dish." Induced pluripotent stem cell (iPSC) technologies now enable studies of organ regeneration and disease modeling in a patient-specific context. We discuss the potential of "organ-on-a-chip" systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic. We propose that the combinatorial studies of human tissues at these two scales would help realize the translational potential of tissue engineering.

Keywords: bioengineering; organ-on-a-chip; pluripotent stem cells; precision medicine; regenerative medicine; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Heart
Humans
Induced Pluripotent Stem Cells*
Lab-On-A-Chip Devices
Regenerative Medicine*
Tissue Engineering

Abstract

Publication types

MeSH terms

Grants and funding