A novel miRNA biomarker panel associated with mortality in pediatric patients with ARDS

Lisa K Lee; Mansoureh Eghbali; Anil Sapru

doi:10.1186/s12931-021-01761-5

A novel miRNA biomarker panel associated with mortality in pediatric patients with ARDS

Respir Res. 2021 Jun 4;22(1):169. doi: 10.1186/s12931-021-01761-5.

Authors

Lisa K Lee¹, Mansoureh Eghbali², Anil Sapru³

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 3325, Los Angeles, CA, 90095, USA. lklee@mednet.ucla.edu.
² Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 3325, Los Angeles, CA, 90095, USA.
³ Division of Pediatric Critical Care, Department of Pediatrics, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, MDCC 488, Los Angeles, CA, 90095, USA.

Abstract

We identified a novel microRNA biomarker panel consisting of 6 microRNAs predicting mortality in pediatric acute respiratory distress syndrome patients. Each of the identified mRNA have potential mechanistic importance in acute respiratory distress syndrome and may lead to the development of pharmacologic targets.

Keywords: ARDS; Biomarkers; Pediatrics; miRNA.

Publication types

Letter

MeSH terms

Biomarkers / metabolism
Child
Child, Preschool
Female
Humans
Male
MicroRNAs / metabolism*
Respiratory Distress Syndrome / genetics*
Respiratory Distress Syndrome / metabolism
Respiratory Distress Syndrome / mortality
Survival Rate / trends

Substances

Biomarkers
MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding