The Interplay Between Thyroid Dysfunction and Kidney Disease

Yoko Narasaki; Peter Sohn; Connie M Rhee

doi:10.1016/j.semnephrol.2021.03.008

The Interplay Between Thyroid Dysfunction and Kidney Disease

Semin Nephrol. 2021 Mar;41(2):133-143. doi: 10.1016/j.semnephrol.2021.03.008.

Authors

Yoko Narasaki¹, Peter Sohn¹, Connie M Rhee²

Affiliations

¹ Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA.
² Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology, Hypertension and Kidney Transplantation, University of California Irvine, Orange, CA. Electronic address: crhee1@uci.edu.

Abstract

Hypothyroidism is a highly prevalent endocrine complication in chronic kidney disease (CKD) patients. A large body of evidence has shown that there is a bidirectional relationship between thyroid dysfunction and kidney disease, yet there are many remaining gaps in knowledge in regards to the clinical management of CKD patients with hypothyroidism, including those receiving hemodialysis and peritoneal dialysis. Given that hypothyroidism has been associated with many deleterious outcomes including a higher risk of (1) mortality, (2) cardiovascular disease, (3) impaired health-related quality of life, and (4) altered body composition in both non-CKD and CKD patients, future research is needed to establish the appropriate screening, diagnosis, and treatment approaches in these populations.

Keywords: Thyroid function; chronic kidney disease; dialysis; hyperthyroidism; hypothyroidism; thyrotropin.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Hypothyroidism* / complications
Peritoneal Dialysis*
Quality of Life
Renal Insufficiency, Chronic* / complications
Renal Insufficiency, Chronic* / therapy

Abstract

Publication types

MeSH terms

Grants and funding