Burden of Respiratory Infection and Tuberculosis Among US States from 1990 to 2019

Wen Zhong; Nicola Luigi Bragazzi; Jude Dzevela Kong; Saeid Safiri; Masoud Behzadifar; Jun Liu; Xinyao Liu; Weijun Wang

doi:10.2147/CLEP.S314802

Burden of Respiratory Infection and Tuberculosis Among US States from 1990 to 2019

Clin Epidemiol. 2021 Jun 29:13:503-514. doi: 10.2147/CLEP.S314802. eCollection 2021.

Authors

Wen Zhong¹, Nicola Luigi Bragazzi², Jude Dzevela Kong², Saeid Safiri^{3

4}, Masoud Behzadifar⁵, Jun Liu¹, Xinyao Liu⁶, Weijun Wang⁷

Affiliations

¹ Department of General Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
² Centre for Disease Modelling, York University, Toronto, Ontario, Canada.
³ Tuberculosis and Lung Disease Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
⁶ Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, People's Republic of China.
⁷ Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Abstract

Purpose: To estimate the incidence, death, disability-adjusted life years (DALYs) and attributable risk factors for respiratory infection and tuberculosis (RIT) in the US from 1990 to 2019.

Methods: Following the methodology framework and analytical strategies used in the Global Burden of Disease Study 2019, the incidence, death, DALYs and risk factors of RIT were examined by age, gender and states from 1990 to 2019 in the US. All estimates were calculated as counts, age-standardized rates per 100,000 people and percentage change, with 95% confidence intervals (CIs).

Results: In 2019, the age-standardized incidence, death and DALY rates per 100,000 people of RIT were 339,703 (95% CI 303,184 to 382,354), 13.6 (95% CI 12.2 to 14.4) and 384.9 (95% CI 330.6 to 458.6), respectively. Among RIT causes, upper respiratory infection accounted for the large majority of RIT age-standardized incidence rate, while lower respiratory infection constituted the highest proportion of RIT age-standardized death and DALY rates. The age-standardized incidence, death and DALY rates of RIT in 2019 and their temporal trends since 1990 varied widely across states and socio-demographic index. Among all attributable risk factors, smoking was the leading one for age-standardized RIT deaths in 2019, followed by low temperature and alcohol use (the attributable fractions were 17.7%, 15.3% and 6.9%, respectively).

Conclusion: Our results suggest that RIT remained a major cause of health burden in the US, with large disparities persisting between US states. Intervention efforts for RIT hotspots, high-risk populations and modifiable risk factors are necessary.

Keywords: United States; disability-adjusted life years; mortality; trend.

Grants and funding

The GBD (Global Burden of Disease) 2017 study was funded by the Bill and Melinda Gates Foundation. The present study was funded by the National Natural Science Foundation of China (No. 81974090).