We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
Keywords: B.1.1.7+E484K; convergent; escape mutation; vaccine; variant of concern.
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.