A search for new derivatives of chiral amino alcohols with an antiarrhythmic activity

M Eckstein; K Tobiasz-Otrebska; D Kadłubowska; B Bartłomowicz; S Kulawiak; B Gawrońska-Szklarz; M Woyke; B Czerny; S Juźwiak

A search for new derivatives of chiral amino alcohols with an antiarrhythmic activity

Pol J Pharmacol Pharm. 1987 May-Jun;39(3):309-15.

Authors

M Eckstein¹, K Tobiasz-Otrebska, D Kadłubowska, B Bartłomowicz, S Kulawiak, B Gawrońska-Szklarz, M Woyke, B Czerny, S Juźwiak

Affiliation

¹ Department of Chemical Technology of Drugs, Medical Academy, Kraków, Poland.

PMID: 3438213

Abstract

Twelve new (R) and (S) Schiff bases and twelve new (R) and (S) 2-benzylamino-1-butanols have been obtained. Pharmacological tests showed a weak antiarrhythmic and hypotensive activity of the screened chiral 2-benzylamino-1-butanols.

MeSH terms

Action Potentials / drug effects
Amino Alcohols / chemical synthesis
Amino Alcohols / pharmacology*
Animals
Anti-Arrhythmia Agents* / chemical synthesis
Drug Evaluation, Preclinical
Female
Guinea Pigs
Heart / drug effects
In Vitro Techniques
Male
Mice
Rats
Rats, Inbred Strains
Schiff Bases / chemical synthesis
Schiff Bases / pharmacology
Stereoisomerism

Substances

Amino Alcohols
Anti-Arrhythmia Agents
Schiff Bases