Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection

Zion Congrave-Wilson; Yesun Lee; Jaycee Jumarang; Stephanie Perez; Jeffrey M Bender; Jennifer Dien Bard; Pia S Pannaraj

doi:10.1001/jama.2021.13967

Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection

JAMA. 2021 Sep 21;326(11):1065-1067. doi: 10.1001/jama.2021.13967.

Authors

Zion Congrave-Wilson¹, Yesun Lee¹, Jaycee Jumarang¹, Stephanie Perez¹, Jeffrey M Bender², Jennifer Dien Bard³, Pia S Pannaraj²

Affiliations

¹ Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California.
² Department of Pediatrics, University of Southern California, Los Angeles.
³ Department of Pathology and Laboratory Medicine, University of Southern California, Los Angeles.

Abstract

This study investigates the timeframe that optimizes saliva sensitivity for SARS-CoV-2 detection using reverse transcriptase–polymerase chain reaction (RT-PCR) testing.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

COVID-19 / diagnosis*
COVID-19 Nucleic Acid Testing / methods*
Humans
Nasopharynx / virology
Reverse Transcriptase Polymerase Chain Reaction
Saliva / virology*
Sensitivity and Specificity

Grants and funding

U01 AI144616/AI/NIAID NIH HHS/United States