Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization

Idy H T Ho; Lhotse H L Ng; Xiaojie Cheng; Tony Gin; Chee Sam Chan; Wuping Sun; Lizu Xiao; Lin Zhang; Matthew T V Chan; William K K Wu; Xiaodong Liu

doi:10.1016/j.ynpai.2021.100071

Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization

Neurobiol Pain. 2021 Aug 2:10:100071. doi: 10.1016/j.ynpai.2021.100071. eCollection 2021 Aug-Dec.

Authors

Idy H T Ho^{1

2}, Lhotse H L Ng^{1

2}, Xiaojie Cheng¹, Tony Gin^{1

2}, Chee Sam Chan¹, Wuping Sun³, Lizu Xiao³, Lin Zhang^{1

2}, Matthew T V Chan^{1

2}, William K K Wu^{1

2

4

5}, Xiaodong Liu^{1

2}

Affiliations

¹ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
² Peter Hung Pain Research Institute, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
³ Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital and the 6 Affiliated Hospital of Shenzhen University Health Science Center, National Key Clinical Pain Medicine of China, Shenzhen 518060, China.
⁴ Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
⁵ State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

Abstract

•ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization.•ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure.

Keywords: ANXA2; MOR1; MOR1 internalization; Remifentanil.