TRIM59: A potential diagnostic and prognostic biomarker in human tumors

PLoS One. 2021 Sep 17;16(9):e0257445. doi: 10.1371/journal.pone.0257445. eCollection 2021.

Abstract

TRIM59 is a protein that is highly expressed in a variety of tumors and promotes tumor development. However, the use of TRIM59 as tumor diagnosis and prognosis biomarker has not been fully explored. We collected datasets from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) to investigate its potential as a biomarker for diagnosis and prognosis. A total of 46 studies, including 11,558 patients were included in this study. Here, we showed that TRIM59 was significantly upregulated in 15 type of human solid tumors in comparison to their adjacent tissues. Receiver operating characteristic curve (ROC) results provided further evidence for the use of TRIM59 as a potential tumor diagnosis biomarker. Overall survival (OS) was compared between TRIM59 high expression and low expression groups. High expression of TRIM59 indicated a poor prognosis in multiple solid tumors. Taken together, these analyses showed that TRIM59 was upregulated in various types of tumors and had the potential to be used as a diagnostic and prognostic biomarker in human solid tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Biomarkers, Tumor / metabolism*
  • Databases, Factual
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Neoplasms / diagnosis*
  • Neoplasms / mortality
  • Neoplasms / pathology
  • Prognosis
  • ROC Curve
  • Survival Analysis
  • Tripartite Motif Proteins / metabolism*
  • Up-Regulation

Substances

  • Biomarkers, Tumor
  • Intracellular Signaling Peptides and Proteins
  • TRIM59 protein, human
  • Tripartite Motif Proteins

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81871245) and Department of Education of Jilin Province (JJKH20190095KJ).