Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19

Hiromu Tanaka; Ho Lee; Atsuho Morita; Ho Namkoong; Shotaro Chubachi; Hiroki Kabata; Hirofumi Kamata; Makoto Ishii; Naoki Hasegawa; Norihiro Harada; Tetsuya Ueda; Soichiro Ueda; Takashi Ishiguro; Ken Arimura; Fukuki Saito; Takashi Yoshiyama; Yasushi Nakano; Yoshikazu Mutoh; Yusuke Suzuki; Koji Murakami; Yukinori Okada; Ryuji Koike; Yuko Kitagawa; Katsushi Tokunaga; Akinori Kimura; Seiya Imoto; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Koichi Fukunaga; Japan COVID-19 Task Force

doi:10.1016/j.ijid.2021.09.070

Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19

Int J Infect Dis. 2021 Dec:113:74-81. doi: 10.1016/j.ijid.2021.09.070. Epub 2021 Sep 30.

Authors

Hiromu Tanaka¹, Ho Lee¹, Atsuho Morita¹, Ho Namkoong², Shotaro Chubachi¹, Hiroki Kabata¹, Hirofumi Kamata¹, Makoto Ishii¹, Naoki Hasegawa², Norihiro Harada³, Tetsuya Ueda⁴, Soichiro Ueda⁵, Takashi Ishiguro⁶, Ken Arimura⁷, Fukuki Saito⁸, Takashi Yoshiyama⁹, Yasushi Nakano¹⁰, Yoshikazu Mutoh¹¹, Yusuke Suzuki¹², Koji Murakami¹³, Yukinori Okada¹⁴, Ryuji Koike¹⁵, Yuko Kitagawa¹⁶, Katsushi Tokunaga¹⁷, Akinori Kimura¹⁸, Seiya Imoto¹⁹, Satoru Miyano²⁰, Seishi Ogawa²¹, Takanori Kanai²², Koichi Fukunaga¹; Japan COVID-19 Task Force

Affiliations

¹ Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
² Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
³ Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
⁴ Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
⁵ JCHO (Japan Community Health Care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
⁶ Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
⁷ Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
⁸ Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
⁹ Fukujuji Hospital, Kiyose, Japan.
¹⁰ Kawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
¹¹ Department of Infectious Diseases, Tosei General Hospital, Seto, Japan.
¹² Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan.
¹³ Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
¹⁴ Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; The Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
¹⁵ Medical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁶ Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
¹⁷ Genome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.
¹⁸ Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁹ Division of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
²⁰ M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
²¹ Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
²² Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Abstract

Background and design: The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. The Japan COVID-19 Task Force is conducting host genome analysis of hospitalized patients with COVID-19 from more than 70 institutions nationwide in Japan. This report describes the clinical characteristics of patients enrolled to date.

Results: The median (interquartile range) age of the 1674 patients included in the analysis was 59 (45-71) years, and more than half of the patients (66.2%) were male. Less than half of the patients (41.2%) had severe disease. The case fatality rate was 3.2%.

Conclusions: Since this is a hospital-based study, the number of severe cases was relatively high, but the case fatality rate was relatively low, when compared to that of other countries. In the future, we will continue to enroll patients and conduct genome analyses of patients with COVID-19.

Keywords: COVID-19; Clinical character; Host genetics; Japan; Pneumonia.

MeSH terms

Advisory Committees
Aged
COVID-19*
Humans
Japan / epidemiology
Male
Middle Aged
Pandemics
SARS-CoV-2