Genetic risk and recombination fraction--an example of non-monotonic dependency

Hum Genet. 1987 Feb;75(2):189-90. doi: 10.1007/BF00591085.

Abstract

The carrier risk for a monogenic disease is not generally monotonously dependent on the recombination fraction between the disease locus and a single marker locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Linkage*
  • Genetic Markers*
  • Humans
  • Models, Genetic*
  • Muscular Dystrophies / genetics
  • Pedigree
  • Recombination, Genetic*
  • Risk
  • X Chromosome

Substances

  • Genetic Markers