Here, we re-emphasize the purpose of our meta-analysis of the associations between carotenoids and subjects with excess body weight (Yao et al., 2021) and address some of the points raised in the commentary by Nafiseh Shokri-mashhadi and Saeed Saadat. The commentary focused on the methodological faults of our published meta-analysis research-but the research was rigorously conducted and scientifically sound, following strictly the relevant requirements of the Cochrane guidelines. Therefore, in the current reply, we included an elaboration and thorough discussion of the search strategy, inclusion and exclusion criteria, and tests of heterogeneity for the discussed meta-analysis in light of the comments made in the commentary. In conclusion, we believe that our study has made an essential contribution to the investigation of the significance of carotenoids in people with excess body weight.