Efficacy of Acyclovir to Suppress Herpes Simplex Virus Oropharyngeal Reactivation in Patients Who Are Mechanically Ventilated: An Ancillary Study of the Preemptive Treatment for Herpesviridae (PTH) Trial

JAMA Netw Open. 2021 Dec 1;4(12):e2139825. doi: 10.1001/jamanetworkopen.2021.39825.

Abstract

This analysis of a randomized clinical trial examines the efficacy of acyclovir for preventing oropharyngeal HSV reactivation among patients who were mechanically ventilated.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / therapeutic use*
  • Adult
  • Aged
  • Antiviral Agents / therapeutic use*
  • Female
  • France
  • Herpes Simplex / prevention & control*
  • Humans
  • Latent Infection / prevention & control*
  • Latent Infection / virology*
  • Male
  • Middle Aged
  • Oropharynx / virology*
  • Respiration, Artificial*
  • Retrospective Studies
  • Virus Shedding

Substances

  • Antiviral Agents
  • Acyclovir