Potential role of neurofilament in COVID-19 and preeclampsia

Athina Samara; Eric Herlenius; Patrick O' Brien; Asma Khalil

doi:10.1016/j.xcrm.2021.100490

Potential role of neurofilament in COVID-19 and preeclampsia

Cell Rep Med. 2022 Jan 18;3(1):100490. doi: 10.1016/j.xcrm.2021.100490.

Authors

Athina Samara^{1

2}, Eric Herlenius^{1

2}, Patrick O' Brien^{3

4}, Asma Khalil^{5

6

7}

Affiliations

¹ Division of Clinical Paediatrics, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
² Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
³ The Royal College of Obstetricians and Gynaecologists, London, UK.
⁴ University College London Hospitals NHS Foundation Trust, London, UK.
⁵ Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK.
⁶ Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.
⁷ Fetal Medicine Unit, Liverpool Women's Hospital, University of Liverpool, Liverpool, UK.

Abstract

Neurofilament light (NFL) is a promising circulating biomarker in preeclampsia and COVID-19, even without evident neurological complications. Several pathways might contribute to the elevated serum NFL levels seen in both pathologies. Future studies will determine whether NFL is a long COVID marker and delineate NFL's role in COVID-19-associated preeclampsia.

Keywords: COVID-19; SARS-CoV-2; hypertension; long COVID; neurofilament; preeclampsia; pregnancy; sNFL.

Publication types

News

MeSH terms

Biomarkers / blood
COVID-19 / blood*
COVID-19 / epidemiology*
COVID-19 / virology
Comorbidity
Female
Humans
Incidence
Neurofilament Proteins / blood*
Pre-Eclampsia / blood*
Pre-Eclampsia / epidemiology*
Pregnancy
SARS-CoV-2*

Substances

Biomarkers
Neurofilament Proteins
neurofilament protein L