Synthesis and Optimization of Deesterified Acacia-Alginate Nanohydrogel for Amethopterin Delivery

T Sathish; N Sabarirajan; S Prasad Jones Christydass; S Sivananthan; R Kamalakannan; V Vijayan; Prabhu Paramasivam

doi:10.1155/2022/7192919

Synthesis and Optimization of Deesterified Acacia-Alginate Nanohydrogel for Amethopterin Delivery

Bioinorg Chem Appl. 2022 Feb 11:2022:7192919. doi: 10.1155/2022/7192919. eCollection 2022.

Authors

T Sathish¹, N Sabarirajan², S Prasad Jones Christydass³, S Sivananthan⁴, R Kamalakannan⁵, V Vijayan⁴, Prabhu Paramasivam⁶

Affiliations

¹ Department of Computer Science and Engineering, Saveetha School of Engineering, SIMATS, Chennai 602105, Tamil Nadu, India.
² Department of Mechanical Engineering, Chendhuran College of Engineering and Technology, Pudukkottai, Tamil Nadu, India.
³ Department of Electrical and Electronics Engineering, K. Ramakrishnan College of Technology, Tiruchirapalli, Tamil Nadu, India.
⁴ Department of Mechanical Engineering, K.Ramakrishnan College of Engineering, Samayapuram, Tiruchirapalli, Tamil Nadu, India.
⁵ Department of Mechanical Engineering, M. Kumarasamy College of Engineering, Karur, Tamil Nadu, India.
⁶ Department of Mechanical Engineering, College of Engineering and Technology, Mettu University, Metu 318, Ethiopia.

Abstract

Naturally obtained materials are preferable for the production of biomedicine in biomedical applications. Acacia gum is has recently become a hopeful one in the biomedicine production due to its excellent properties, namely, emulsifier, stabilizing mediator, suspending agent, etc. In this novel work, we synthesised and characterized the deesterified Acacia gum-alginate nanohydrogel (DEA-AG NPs) as a carrier for amethopterin (ATN) delivery. This combination is used in the drug effectiveness and tissue engineering. In this work, the Taguchi route is implemented for estimating of particle size and zeta potential (mV) through optimization. Following three parameters are considered for this work: DEA solution concentration (0.008, 0.016, 0.024, and 0.032 w/v %), alginate molecular weight (3, 6, 9, and 12 MW), and ATN/DEA ratio (1 : 4, 1 : 8, 1 : 12, and 1 : 16 w/w %). In particle size analysis and zeta potential analysis, the DEA solution concentration is highly influenced. Minimum particle size is found as 148.50 nm. Similarly, maximum zeta potential is identified as 29.5 mV.