An extremely rare mucocutaneous adverse reaction following COVID-19 vaccination: Toxic epidermal necrolysis

Dermatol Ther. 2022 May;35(5):e15416. doi: 10.1111/dth.15416. Epub 2022 Mar 9.

Abstract

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), is a type of delayed hypersensitivity reaction that requires urgent medical intervention. In the COVID-19 era, COVID-19 vaccines are currently being widely administered and mucocutaneous adverse reactions following vaccination have been reported; however, severe cutaneous adverse reactions associated with COVID-19 vaccines including SJS/TEN, are extremely rare. Herein, we describe a case of COVID-19 vaccination induced TEN which developed 1 day after receiving the first dose of Sinopharm COVID-19 vaccine with favorable clinical outcome.

Keywords: COVID-19; Lyell's syndrome; Stevens-Johnson syndrome; erythema multiforme; vaccination.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 Vaccines / adverse effects
  • COVID-19* / prevention & control
  • Humans
  • Skin
  • Stevens-Johnson Syndrome* / diagnosis
  • Stevens-Johnson Syndrome* / etiology
  • Vaccination

Substances

  • COVID-19 Vaccines