Metabolic determinants of NAFLD in adults with type 1 diabetes

M Serdarova; R Dimova; N Chakarova; G Grozeva; A Todorova; P Tsarkova; C Marinova; D Popov; L Mateva; T Tankova

doi:10.1016/j.diabres.2022.109819

Metabolic determinants of NAFLD in adults with type 1 diabetes

Diabetes Res Clin Pract. 2022 Apr:186:109819. doi: 10.1016/j.diabres.2022.109819. Epub 2022 Mar 3.

Authors

M Serdarova¹, R Dimova², N Chakarova², G Grozeva², A Todorova², P Tsarkova², C Marinova³, D Popov³, L Mateva³, T Tankova²

Affiliations

¹ Department of Endocrinology, Medical University of Sofia, Bulgaria. Electronic address: serdarovamina@gmail.com.
² Department of Endocrinology, Medical University of Sofia, Bulgaria.
³ Department of Internal Diseases, Medical University of Sofia, Bulgaria.

PMID: 35248654
DOI: 10.1016/j.diabres.2022.109819

Abstract

Aim: To assess the main metabolic determinants of non-alcoholic fatty liver disease (NAFLD) in adult patients with type 1 diabetes (T1D).

Methods: 115 patients with T1D were divided into 4 groups according to NAFLD grade. NAFLD was diagnosed via transient elastography when CAP > 233 dB/m. Body composition was evaluated by Inbody720, Biospace. Serum lipids, liver enzymes, uric acid, creatinine, hsCRP and HbA1c were evaluated at fasting.

Results: The overall prevalence of NAFLD was 47% (n = 54). In the subgroup with BMI > 25 kg/m² NAFLD prevalence was 66%; and positive family history of type 2 diabetes brought the risk up to 76%. 37% of the lean individuals also had NAFLD. HbA1c > 7% doubled the risk of NAFLD. Waist circumference > 82.5 cm was independently related to NAFLD, accounting for 24% of its variation in females. Accumulation of two and three metabolic syndrome (MetS) components, besides hyperglycemia, increased the risk of NAFLD by 14% (p < 0.0001) and 6% (p = 0.024), respectively. Lean NAFLD correlated with total insulin dose; NAFLD in overweight T1D patients correlated with triglycerides.

Conclusions: NAFLD is highly prevalent in adults with T1D and obesity or other metabolic derangements and might be independently related to poor long-term glycemic control and waist circumference in females.

Keywords: Metabolic determinants; Non-alcoholic fatty liver disease (NAFLD); Type 1 diabetes.

MeSH terms

Adult
Body Mass Index
Diabetes Mellitus, Type 1* / complications
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Female
Glycated Hemoglobin
Humans
Metabolic Syndrome* / diagnosis
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / epidemiology
Prevalence
Risk Factors
Waist Circumference

Substances

Glycated Hemoglobin A