The Immunogenetics of Lichen Planus

Parvin Mansouri; Nahid Nikkhah; Behnaz Esmaeili; Alireza Khosravi; Reza Chalangari; Katalin Martits-Chalangari

doi:10.1007/978-3-030-92616-8_5

The Immunogenetics of Lichen Planus

Adv Exp Med Biol. 2022:1367:119-135. doi: 10.1007/978-3-030-92616-8_5.

Authors

Parvin Mansouri¹, Nahid Nikkhah², Behnaz Esmaeili³, Alireza Khosravi⁴, Reza Chalangari⁵, Katalin Martits-Chalangari⁵

Affiliations

¹ Research Vice-President of Medical Laser Research Center, Academic Center for Education-Culture and Research, Tehran University of Medical Sciences, Tehran, Iran. mansorip@sina.tums.ac.ir.
² Medical Laser Research Centers, Academic Center for Education-Culture and Research, Tehran University of Medical Sciences, Tehran, Iran.
³ Immunology Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
⁵ Kasir Dermatology, Dallas, TX, USA.

PMID: 35286694
DOI: 10.1007/978-3-030-92616-8_5

Abstract

Lichen planus (LP) is a multifaceted autoimmune disease affecting the skin, nails, hair, and mucous membranes, with several clinical subgroups. Cell-mediated immunity plays a key role in its progression. This chapter reviews the known genetic associations of lichen planus including HLA as well as non-HLA genes.

Keywords: Classic lichen plan; Cutaneous lichen plan; GWAS; Immunogenetics; Immunogenetics of lichen planus; Lichen planopilaris; Lichen planus; Mucosal lichen plan; Pathogenesis; Single nucleotide polymorphism.

MeSH terms

Autoimmune Diseases*
Hair
Humans
Immunogenetics
Lichen Planus* / genetics
Skin