Locally produced autoantibodies in cancer

Sara M Centuori; Deepta Bhattacharya

doi:10.1016/j.cell.2022.03.006

Locally produced autoantibodies in cancer

Cell. 2022 Mar 31;185(7):1110-1111. doi: 10.1016/j.cell.2022.03.006.

Authors

Sara M Centuori¹, Deepta Bhattacharya²

Affiliations

¹ Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA; University of Arizona Cancer Center, Tucson, AZ, USA.
² Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA. Electronic address: deeptab@arizona.edu.

PMID: 35364029
DOI: 10.1016/j.cell.2022.03.006

Abstract

The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Autoantibodies*
Autoantigens
B-Lymphocytes
Female
Humans
Ovarian Neoplasms*

Substances

Autoantibodies
Autoantigens

Abstract

Publication types

MeSH terms

Substances

Grants and funding