Impact of COPD or Asthma on the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis

Zhengbiao Xue; Siyu Guo; Xiao Liu; Jianyong Ma; Wengen Zhu; Yue Zhou; Fuwei Liu; Jun Luo

doi:10.3389/fcvm.2022.872446

Impact of COPD or Asthma on the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis

Front Cardiovasc Med. 2022 Apr 11:9:872446. doi: 10.3389/fcvm.2022.872446. eCollection 2022.

Authors

Zhengbiao Xue¹, Siyu Guo^{2

3}, Xiao Liu⁴, Jianyong Ma⁵, Wengen Zhu⁶, Yue Zhou⁷, Fuwei Liu², Jun Luo²

Affiliations

¹ Department of Critial Care Medicine, The First Affiliated Hosptial of Gannan Medical University, Ganzhou, China.
² Department of Cardiology, The Affiliated Ganzhou Hospital of Nanchang University, Guangzhou, China.
³ Medical Department, Queen Mary school, Nanchang University, Nanchang, China.
⁴ Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
⁵ Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
⁶ Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Ganzhou, China.
⁷ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Abstract

Background: Respiratory diseases related to chronic pulmonary ventilation dysfunction are mainly composed of chronic obstructive pulmonary disease (COPD) and asthma. Our meta-analysis aimed to illustrate the association of COPD or asthma with risk of atrial fibrillation (AF).

Methods: We systematically searched the databases of the PubMed, Embase, and Cochrane library until December 2021 for studies focusing on the relationship between COPD or asthma and AF risk. Due to the potential heterogeneity across studies, the random-effects model was used to pool the studies.

Results: Our meta-analysis included 14 studies. Based on the random-effects model, the pooled analysis showed that COPD (risk ratio[RR] = 1.74, 95% confidence interval [CI]: 1.70-1.79) and asthma (RR = 1.08, 95% CI: 1.04-1.12) were significantly associated with an increased risk of AF. The results did not change after each study was excluded.

Conclusion: Our current data suggested that COPD or asthma with associated with an increased risk of AF.

Keywords: asthma; atrial fibrillation; chronic obstructive pulmonary disease; meta-analysis; risk factor.

Publication types

Systematic Review