Vitamin D replacement in children with acute wheeze: a dose-escalation study

Christos Stefanidis; Andrew Bush; Christopher Newby; Chinedu Nwokoro; Susan Liebeschuetz; Imogen P Skene; Christopher J Griffiths; Adrian R Martineau

doi:10.1183/23120541.00609-2021

Vitamin D replacement in children with acute wheeze: a dose-escalation study

ERJ Open Res. 2022 May 16;8(2):00609-2021. doi: 10.1183/23120541.00609-2021. eCollection 2022 Apr.

Authors

Christos Stefanidis¹, Andrew Bush², Christopher Newby¹, Chinedu Nwokoro¹, Susan Liebeschuetz³, Imogen P Skene⁴, Christopher J Griffiths¹, Adrian R Martineau¹

Affiliations

¹ Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
² Asthma UK Centre for Applied Research; Imperial College and Royal Brompton Hospital, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK.
³ Dept of Paediatrics, Newham University Hospital, London, UK.
⁴ Emergency Department Research Office, Royal London Hospital, Whitechapel, London, UK.

Abstract

Vitamin D supplementation at the current UK recommended level (400 IU·day^-1) or enhanced supplementation (1000 IU·day^-1) failed to achieve adequate levels of vitamin D (>75 nmol·L^-1) in vitamin-D-insufficient children with acute wheeze https://bit.ly/3J43Ouo.