Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling

Intensive Care Med. 2022 Aug;48(8):1122-1124. doi: 10.1007/s00134-022-06741-x. Epub 2022 May 27.

Roberta M L Roepke^{1

2}, Pedro V Mendes³, Luis C M Cardozo Junior³, Marcelo Park³, Bruno A M P Besen^{4

5}

¹ Trauma and Acute Care Surgery ICU, Department of Surgery, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
² Intensive Care Unit, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
³ Medical ICU, Department of Medicine, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
⁴ Intensive Care Unit, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. brunobesen@yahoo.com.br.
⁵ Medical ICU, Department of Medicine, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255, 11th Floor, Room 11083, São Paulo, SP, 05403-000, Brazil. brunobesen@yahoo.com.br.

No abstract available

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