A multicenter prospective study on quality of life and pain relief for cancer patient after 125I seed implantation

Jingxuan Zhang; Qiuyu Sun; Lan Gao; Lijuan Sun; Chunxue Wang; Baohua Li; Junjie Wang; Panfeng Wang

doi:10.1016/j.apjon.2022.04.004

A multicenter prospective study on quality of life and pain relief for cancer patient after ¹²⁵I seed implantation

Asia Pac J Oncol Nurs. 2022 Apr 13;9(8):100065. doi: 10.1016/j.apjon.2022.04.004. eCollection 2022 Aug.

Authors

Jingxuan Zhang¹, Qiuyu Sun¹, Lan Gao², Lijuan Sun³, Chunxue Wang², Baohua Li⁴, Junjie Wang¹, Panfeng Wang¹

Affiliations

¹ Radiation Oncology Department, Peking University Third Hospital, Beijing, China.
² Interventional and Vascular Surgery Department, Southeast University Zhongda Hospital, Nanjing, China.
³ Oncology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
⁴ Neurology Department, Peking University Third Hospital, Beijing, China.

Abstract

Objective: To prospectively explore the efficacy of ¹²⁵I seed implantation on quality of life and pain relief in cancer patient.

Methods: Consecutive cancer patients who underwent ¹²⁵I seed implantation in three centers in China between October 1, 2020 and March 31, 2021, were assessed. The Functional Assessment of Cancer Therapy and Brief Pain Inventory were used to evaluate patients' quality of life and pain relief on the day before, 1 week, 1 month, and 3 months after seed implantation.

Results: A total of 104 cancer patients were enroled. Total score of quality of life was not statistically different 3 months after seed implantation compared with before implantation, while patients' quality of life was worse one week after seed implantation but then recovered. A total of 43 (41.3%) patients had pain before seed implantation, of which 16 (37.2%) patients had severe pain and 27 (62.8%) had mild-to-moderate pain. In patients with severe pain, the worst pain scores decreased significantly 3 months after implantation. In patients with mild-to-moderate pain, pain severity and pain interference score increased significantly after implantation compared with pre-implantation. Compared with pain before implantation, patients' quality of life of patients without pain was higher.

Conclusions: ¹²⁵I seed implantation maintains the quality of life of patients within 3 months. For patients with severe pain, seed implantation has obvious pain relief, which improves the quality of life of the patients. Nurses should provide personalized guidance for patients with different degrees of pain.

Keywords: 125I seed implantation; Cancer; Nursing; Pain; Quality of life.