Gait Parameters and Peripheral Neuropathy in Patients With Diabetes: A Meta-Analysis

Zhenchao Wang; Si Peng; Honghong Zhang; Hong Sun; Ji Hu

doi:10.3389/fendo.2022.891356

Gait Parameters and Peripheral Neuropathy in Patients With Diabetes: A Meta-Analysis

Front Endocrinol (Lausanne). 2022 Jun 1:13:891356. doi: 10.3389/fendo.2022.891356. eCollection 2022.

Authors

Zhenchao Wang¹, Si Peng^{1

2}, Honghong Zhang¹, Hong Sun³, Ji Hu¹

Affiliations

¹ Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
² Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
³ Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Abstract

Objective: To investigate the relationship between diabetic peripheral neuropathy (DPN) and gait abnormality in diabetic patients.

Methods: Related research concerning the gait of diabetic patients with and without DPN was collected and analyzed by searching PubMed, Embase, and Web of Science. Statistical analysis was performed by using RevMan 5.3 software.

Results: Twenty-one studies were included in this meta-analysis, consisting of 499 diabetic neuropathy patients and 467 diabetes controls without neuropathy. Meta-analysis results showed lower gait velocity, shorter stride length, longer stride time, longer stance time, and higher maximum knee extension moment in the DPN group, compared with their counterparts.

Conclusion: Among diabetic patients, those complicated with DPN possess lower gait velocity, shorter stride length, longer stride time, longer stance time, and higher maximum knee extension moment.

Keywords: DPN; diabetes mellitus; gait abnormalities; gait parameters; meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus*
Diabetic Neuropathies* / complications
Gait
Humans
Knee Joint