Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021

Heidi L Moline; Amelia Keaton; Whitney Rice; Jasmine Varghese; Li Deng; Ansley Waters; Anna Barringer; Devonne Winston; Virgie Fields; Kara Jacobs Slifka; Jennifer R Verani; Stephanie J Schrag; John Jernigan; Jacqueline E Tate; Katherine E Fleming-Dutra

doi:10.1093/cid/ciac526

Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021

Clin Infect Dis. 2022 Oct 3;75(Suppl 2):S155-S158. doi: 10.1093/cid/ciac526.

Authors

Heidi L Moline^{1

2}, Amelia Keaton¹, Whitney Rice³, Jasmine Varghese¹, Li Deng¹, Ansley Waters^{4

5}, Anna Barringer³, Devonne Winston³, Virgie Fields⁵, Kara Jacobs Slifka¹, Jennifer R Verani¹, Stephanie J Schrag¹, John Jernigan¹, Jacqueline E Tate¹, Katherine E Fleming-Dutra¹

Affiliations

¹ COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
³ Virginia Beach Health Department, Virginia Beach, Virginia, USA.
⁴ Council of State and Territorial Epidemiologists,, Atlanta, GA, USA.
⁵ Virginia Department of Health, Richmond, Virginia, USA.

Abstract

In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval: 25-84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.

Keywords: SARS-CoV-2; skilled nursing facility; vaccine effectiveness.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

MeSH terms

COVID-19 Vaccines
COVID-19* / epidemiology
COVID-19* / prevention & control
Disease Outbreaks / prevention & control
Humans
RNA, Messenger
SARS-CoV-2* / genetics
Vaccines, Synthetic
Virginia
mRNA Vaccines

Substances

COVID-19 Vaccines
RNA, Messenger
Vaccines, Synthetic
mRNA Vaccines

Supplementary concepts

SARS-CoV-2 variants