Antibiotic treatment ignites a fire that lasts

Iván C Acosta; Francis Alonzo 3rd

doi:10.1016/j.chom.2022.06.001

Antibiotic treatment ignites a fire that lasts

Cell Host Microbe. 2022 Jul 13;30(7):897-899. doi: 10.1016/j.chom.2022.06.001.

Authors

Iván C Acosta¹, Francis Alonzo 3rd²

Affiliations

¹ Department of Microbiology and Immunology, Loyola University Chicago - Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA.
² Department of Microbiology and Immunology, Loyola University Chicago - Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA. Electronic address: falonzo@luc.edu.

PMID: 35834957
DOI: 10.1016/j.chom.2022.06.001

Abstract

Tissue damage and persistent inflammation are distinctive features of antibiotic-resistant chronic infections. In this issue of Cell Host & Microbe, Tang et al. demonstrate that anti-folate antibiotics trigger the synthesis of a bacterial second messenger, which induces an exuberant immune response and establishes a paradigm for chronic infection.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Bacterial Agents* / therapeutic use
Bacteria*

Substances

Anti-Bacterial Agents