A rare case of cardiac toxicity in a patient with imatinib treatment: Case report

J Cancer Res Ther. 2022 Apr-Jun;18(3):792-794. doi: 10.4103/jcrt.JCRT_188_19.

Abstract

Imatinib, a tyrosine kinase inhibitor, primarily used to treat chronic myeloid leukemia, has shown a survival benefit in gastrointestinal stromal tumors (GISTs). The most common toxicities of imatinib include fluid retention, diarrhea, nausea, fatigue, muscle cramps, abdominal pain, and rash. Imatinib-related cardiotoxicity is a rare condition, and its clinical severity varies between asymptomatic mild ventricular dysfunction and severe congestive heart failure (CHF). We report the case of a 64-year-old woman with a history of GIST who presented to our clinic with rapidly progressive dyspnea. After 8 weeks of imatinib treatment, the patient developed CHF. Echocardiography showed decreased ejection fraction. Imatinib was stopped and diuretic therapy was started. Two weeks later, she died. Cardiac shock was her cause of death.

Keywords: Cardiac toxicity; gastrointestinal stromal tumors; imatinib.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Benzamides / therapeutic use
  • Cardiotoxicity / diagnosis
  • Cardiotoxicity / etiology
  • Female
  • Gastrointestinal Stromal Tumors* / drug therapy
  • Gastrointestinal Stromal Tumors* / pathology
  • Humans
  • Imatinib Mesylate / adverse effects
  • Middle Aged
  • Piperazines / therapeutic use
  • Pyrimidines / adverse effects

Substances

  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate