A case of recurrent viral retinitis treated with intravitreal antiviral agents in a silicone oil filled eye

Eur J Ophthalmol. 2023 Sep;33(5):NP124-NP129. doi: 10.1177/11206721221118142. Epub 2022 Aug 7.

Abstract

Purpose: To report a case of recurrent acute retinal necrosis (ARN) in an eye filled with silicone oil previously complicated by rhegmatogenous retinal detachment (RRD).

Observations: A 68-year-old gentlemen with successfully treated herpes simplex virus type 1 (HSV1) ARN complicated by RRD requiring pars plana vitrectomy (PPV) with silicone oil tamponade, presented with a relapse of ARN with silicone oil in situ. Remission of recurrent retinitis was achieved using combined systemic oral and intravitreal antiviral therapy.

Conclusions and importance: RRD is a significant complication of ARN which may require surgery with silicone oil tamponade. Recurrence of ARN retinitis can be effectively treated with intravitreal Ganciclovir and Foscarnet injections in a silicone oil filled eye with concurrent oral antiviral therapy. Aqueous humour sampling proved useful in the monitoring of disease activity.

Keywords: Intravitreal therapy; antiviral; retinal detachment; retinitis.; silicone oil.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiviral Agents / therapeutic use
  • Eye Infections, Viral* / complications
  • Eye Infections, Viral* / diagnosis
  • Eye Infections, Viral* / drug therapy
  • Humans
  • Retinal Detachment* / diagnosis
  • Retinal Detachment* / drug therapy
  • Retinal Detachment* / surgery
  • Retinal Necrosis Syndrome, Acute* / complications
  • Retinal Necrosis Syndrome, Acute* / diagnosis
  • Retinal Necrosis Syndrome, Acute* / drug therapy
  • Retinitis*
  • Retrospective Studies
  • Silicone Oils
  • Vitrectomy / adverse effects

Substances

  • Antiviral Agents
  • Silicone Oils