Effect of periodontal treatment on glycated haemoglobin and metabolic syndrome parameters: A randomized clinical trial

Fernanda C Milanesi; Bruna F Greggianin; Gabriela O Dos Santos; Mirian P Toniazzo; Patricia Weidlich; Fernando Gerchman; Rui V Oppermann

doi:10.1111/jcpe.13717

Effect of periodontal treatment on glycated haemoglobin and metabolic syndrome parameters: A randomized clinical trial

J Clin Periodontol. 2023 Jan;50(1):11-21. doi: 10.1111/jcpe.13717. Epub 2022 Aug 27.

Authors

Fernanda C Milanesi¹, Bruna F Greggianin¹, Gabriela O Dos Santos¹, Mirian P Toniazzo¹, Patricia Weidlich², Fernando Gerchman³, Rui V Oppermann²

Affiliations

¹ Post-graduate Program in Dentistry: Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
² Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
³ Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

PMID: 36053828
DOI: 10.1111/jcpe.13717

Abstract

Aim: To assess the effect of periodontal treatment on HbA1c and diagnostic parameters of patients with metabolic syndrome (MetS).

Materials and methods: One hundred and fifty-eight patients with MetS and moderate and severe periodontitis were included. They were randomized into a test group (n = 79), which received non-surgical periodontal treatment, and a control group (n = 79), which received no treatment. Medical treatment was delivered to both groups. Clinical periodontal, anthropometric and serological parameters were assessed at baseline, 3 and 6 months. The main outcome was glycated haemoglobin (HbA1c) levels, and the secondary outcomes were changes in the MetS parameters, C-reactive protein (CRP) and HOMA indexes.

Results: Significant reductions in all periodontal parameters were observed in the test group, compared with the control group, at 3 and 6 months (p < .001). HbA1c levels, MetS parameters, CRP and HOMA indexes showed no significant differences between the test group and the control group at 3 and 6 months.

Conclusions: Periodontal treatment led to a substantial reduction in periodontal inflammation, although there was no significant effect on the parameters used for MetS diagnosis in patients with early diagnosed and well-controlled MetS.

Keywords: metabolic syndrome; periodontitis; randomized controlled trial.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

C-Reactive Protein / analysis
Chronic Periodontitis* / complications
Chronic Periodontitis* / therapy
Dental Scaling
Diabetes Mellitus, Type 2* / complications
Glycated Hemoglobin
Humans
Metabolic Syndrome* / complications
Metabolic Syndrome* / therapy
Root Planing

Substances

Glycated Hemoglobin
C-Reactive Protein