Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Alice Y Guh; Sarah H Yi; James Baggs; Lisa Winston; Erin Parker; Helen Johnston; Elizabeth Basiliere; Danyel Olson; Scott K Fridkin; Nirja Mehta; Lucy Wilson; Rebecca Perlmutter; Stacy M Holzbauer; Paige D'Heilly; Erin C Phipps; Kristina G Flores; Ghinwa K Dumyati; Trupti Hatwar; Rebecca Pierce; Valerie L S Ocampo; Christopher D Wilson; Jasmine J Watkins; Lauren Korhonen; Ashley Paulick; Michelle Adamczyk; Dale N Gerding; Sujan C Reddy

doi:10.1093/ofid/ofac422

Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Open Forum Infect Dis. 2022 Aug 17;9(9):ofac422. doi: 10.1093/ofid/ofac422. eCollection 2022 Sep.

Authors

Alice Y Guh¹, Sarah H Yi¹, James Baggs¹, Lisa Winston², Erin Parker³, Helen Johnston⁴, Elizabeth Basiliere⁴, Danyel Olson⁵, Scott K Fridkin⁶, Nirja Mehta⁶, Lucy Wilson⁷, Rebecca Perlmutter⁸, Stacy M Holzbauer^{9

10}, Paige D'Heilly⁹, Erin C Phipps¹¹, Kristina G Flores¹¹, Ghinwa K Dumyati¹², Trupti Hatwar¹², Rebecca Pierce¹³, Valerie L S Ocampo¹³, Christopher D Wilson¹⁴, Jasmine J Watkins¹⁴, Lauren Korhonen¹, Ashley Paulick¹, Michelle Adamczyk¹, Dale N Gerding¹⁵, Sujan C Reddy¹

Affiliations

¹ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA.
³ California Emerging Infections Program, Oakland, California, USA.
⁴ Colorado Department of Public Health and Environment, Denver, Colorado, USA.
⁵ Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA.
⁶ Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
⁷ Department of Emergency Health Services, University of Maryland Baltimore County, Baltimore, Maryland, USA.
⁸ Maryland Department of Health, Baltimore, Maryland, USA.
⁹ Minnesota Department of Health, St. Paul, Minnesota, USA.
¹⁰ Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
¹¹ New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico, USA.
¹² Department of Medicine, New York Emerging Infections Program and University of Rochester Medical Center, Rochester, New York, USA.
¹³ Oregon Health Authority, Portland, Oregon, USA.
¹⁴ Tennessee Department of Health, Nashville, Tennessee, USA.
¹⁵ Departments of Medicine and Research, Edward Hines, Jr. Veterans Affairs Hospital, Hines, Illinois, USA.

Abstract

Among persons with an initial Clostridioides difficile infection (CDI) across 10 US sites in 2018 compared with 2013, 18.3% versus 21.1% had ≥1 recurrent CDI (rCDI) within 180 days. We observed a 16% lower adjusted risk of rCDI in 2018 versus 2013 (P < .0001).

Keywords: Clostridioides difficile; infection; recurrent.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

Abstract

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