Consensus statement on heart xenotransplantation in children: Toward clinical translation

Igor E Konstantinov; David K C Cooper; Iki Adachi; Emile Bacha; Mark S Bleiweis; Richard Chinnock; David Cleveland; Peter J Cowan; Francis Fynn-Thompson; David L S Morales; Muhammad M Mohiuddin; Bruno Reichart; Martine Rothblatt; Nathalie Roy; Joseph W Turek; Simon Urschel; Lori West; Eckhard Wolf

doi:10.1016/j.jtcvs.2022.09.001

Consensus statement on heart xenotransplantation in children: Toward clinical translation

J Thorac Cardiovasc Surg. 2023 Sep;166(3):960-967. doi: 10.1016/j.jtcvs.2022.09.001. Epub 2022 Sep 6.

Authors

Igor E Konstantinov¹, David K C Cooper², Iki Adachi³, Emile Bacha⁴, Mark S Bleiweis⁵, Richard Chinnock⁶, David Cleveland⁷, Peter J Cowan⁸, Francis Fynn-Thompson⁹, David L S Morales¹⁰, Muhammad M Mohiuddin¹¹, Bruno Reichart¹², Martine Rothblatt¹³, Nathalie Roy⁹, Joseph W Turek¹⁴, Simon Urschel¹⁵, Lori West¹⁶, Eckhard Wolf¹⁷

Affiliations

¹ Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Melbourne, Australia. Electronic address: igor.konstantinov@rch.org.au.
² Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, Mass.
³ Texas Children's Hospital, Baylor College of Medicine, Houston, Tex.
⁴ Columbia University Medical Center, Morgan Stanley Children's Hospital, New York, NY.
⁵ University of Florida, Gainesville, Fla.
⁶ Loma Linda University Children's Hospital, Loma Linda, Calif.
⁷ Department of Surgery, University of Alabama, Birmingham, Ala.
⁸ Immunology Research Centre, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.
⁹ Boston Children's Hospital, Harvard Medical School, Boston, Mass.
¹⁰ Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹¹ Program in Cardiac Xenotransplantation, University of Maryland School of Medicine, Baltimore, Md.
¹² Transregional Collaborative Research Center, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany.
¹³ United Therapeutics, Silver Spring, Md.
¹⁴ Department of Surgery, Duke University Medical Center, Durham, NC.
¹⁵ Pediatric Cardiac Transplantation Program, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada.
¹⁶ Pediatric Cardiac Transplantation Program, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada; Canadian Donation and Transplantation Research Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada.
¹⁷ Gene Center and Department of Veterinary Sciences, Ludwig Maximilians University, Munich, Germany.

PMID: 36184321
PMCID: PMC10124772 (available on 2024-09-01)
DOI: 10.1016/j.jtcvs.2022.09.001

Abstract

Keywords: congenital heart disease; genetically engineered; heart; infants; neonates; pediatric; pig; xenotransplantation.

Publication types

Editorial

MeSH terms

Animals
Animals, Genetically Modified
Child
Genetic Engineering*
Graft Rejection
Heart*
Humans
Thorax
Transplantation, Heterologous

Grants and funding

U19 AI090959/AI/NIAID NIH HHS/United States