Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization

Fengshi Li; Zhihua Rong; Rui Zhang; Shuai Niu; Xiao Di; Leng Ni; Changwei Liu

doi:10.1016/j.isci.2022.105147

Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization

iScience. 2022 Sep 16;25(10):105147. doi: 10.1016/j.isci.2022.105147. eCollection 2022 Oct 21.

Authors

Fengshi Li¹, Zhihua Rong¹, Rui Zhang¹, Shuai Niu¹, Xiao Di¹, Leng Ni¹, Changwei Liu¹

Affiliation

¹ Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People's Republic of China.

Abstract

Vascular restenosis is the main factor affecting the prognosis of angioplasty in cardiovascular diseases, and inflammation is a central link in the progression of restenosis. Previous research that applies interleukin 10 (IL10) nanoparticles can effectively regulate local inflammation, but their targeted delivery efficacy remains to be improved. In this study, IL10 nanoparticles were successfully prepared and then coated by a preactive platelet membrane. The ability to target and regulate macrophage polarization has been demonstrated, thereby regulating smooth muscle cell and endothelial cell functions. In vivo experiments were carried out in a carotid artery injury model and verified the above functions and the effect on inhibiting vascular restenosis. Immune regulation-based platelet membrane coated nanoparticle loaded with IL10 proved to be an excellent candidate for targeting vascular injury and holds promise as an innovative drug delivery system for suppressing vascular restenosis.

Keywords: Drug delivery system; immune response; nanoparticles.