Mechanosensation: Capping actin filaments for robustness

Alex Mogilner; Christopher E Miles

doi:10.1016/j.cub.2022.09.025

Mechanosensation: Capping actin filaments for robustness

Curr Biol. 2022 Oct 24;32(20):R1033-R1035. doi: 10.1016/j.cub.2022.09.025.

Authors

Alex Mogilner¹, Christopher E Miles²

Affiliations

¹ Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA; Department of Biology, New York University, 100 Washington Square East, 1009 Silver Center, New York, NY 10003, USA. Electronic address: mogilner@cims.nyu.edu.
² Department of Mathematics, University of California, Irvine, 419 Rowland Hall, Irvine, CA 92697, USA.

PMID: 36283352
DOI: 10.1016/j.cub.2022.09.025

Abstract

Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.

MeSH terms

Actin Cytoskeleton*
Actins*

Substances

Actins