Ethnopharmacology and biological activities of the Aizoaceae

B Kalicharan; Y Naidoo; J van Staden

doi:10.1016/j.jep.2022.115988

Ethnopharmacology and biological activities of the Aizoaceae

J Ethnopharmacol. 2023 Mar 1:303:115988. doi: 10.1016/j.jep.2022.115988. Epub 2022 Nov 29.

Authors

B Kalicharan¹, Y Naidoo², J van Staden³

Affiliations

¹ School of Life Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa; Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa.
² School of Life Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
³ Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa. Electronic address: rcpgd@ukzn.ac.za.

PMID: 36460295
DOI: 10.1016/j.jep.2022.115988

Abstract

Ethnopharmacological relevance: The Aizoaceae is one of the largest succulent plant families. Most members of the family are ornamental and form part of specialist succulent collections. The exceptional diversity of the Aizoaceae is not only limited to its growth forms, habitat, and chemistry, but is also reflected in its many traditional uses. Selected species are well known for their use in traditional medicines, with recent scientific studies validating their biological activity.

Aim of the study: Herein, this review aimed to articulate foundational and current global research endeavors related to the traditional uses and pharmacological activities of the Aizoaceae.

Materials and methods: Research articles and search terms related to the ethnopharmacology and bioactivities of the Aizoaceae between 1940 and 2022 were evaluated using electronic databases such as Google Scholar, PubMed, ScienceDirect, Scopus, JSTOR, and Web of Science.

Results: Popular Aizoaceae genera including Mesembryanthemum, Trianthema, and Tetragonia are noted for their cultural value and are key components in herbal medicines for the treatment of a myriad of disorders. Isolated bioactive compounds isolated from selected species demonstrated varied antimicrobial, antioxidant, and neuroprotective functions in basic pharmacological studies. However, most studies lacked reliable correlation to in vivo activity and did not adequately validate the safety and efficacy of potential therapeutic compounds.

Conclusions: While the cultural and therapeutic value of popular Aizoaceae species have been highlighted in the literature, there remains glaring inconsistencies among other related species. Data deficiency may be ameliorated by further studies focused on taxonomic markers, chemical characterization and underlying molecular mechanisms of activity of a wider pool of species to enhance our knowledge of this hyperdiverse family.

Keywords: Aizoaceae; Antimicrobial; Antioxidant; Cosmetics; Mesembryanthemum; Succulent.

Publication types

Review

MeSH terms

Aizoaceae*
Ethnopharmacology
Medicine, Traditional
Phytochemicals / chemistry
Phytochemicals / pharmacology
Phytochemicals / therapeutic use
Phytotherapy
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plants, Medicinal*

Substances

Phytochemicals
Plant Extracts