Thyroid Eye Disease

Life (Basel). 2022 Dec 12;12(12):2084. doi: 10.3390/life12122084.

Abstract

Thyroid eye disease (TED), an autoimmune inflammatory disorder of the orbit, presents with a potential array of clinical sequelae. The pathophysiology behind TED has been partially characterized in the literature. There remain certain elusive mechanisms welcoming of research advances. Disease presentation can vary, but those that follow a characteristic course start mild and increase in severity before plateauing into an inactive phase. Diagnosis and evaluation include careful physical examination, targeted laboratory work up, appropriate imaging studies, and tailored treatment regimens. Special consideration may apply to certain populations, such as pediatric and pregnant patients.

Keywords: Grave’s disease; Hashimoto’s thyroiditis; chronic lymphocytic thyroiditis; euthyroid eye disease; exophthalmos; orbital inflammation; proptosis; teprotumumab; thyroid eye disease; thyroid-associated orbitopathy.

Publication types

  • Review

Grants and funding

This research received no external funding.