Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Variants on Short- and Mid-term Cardiac Outcomes in Multisystem Inflammatory Syndrome in Children

Swetha Pinninti; Camden Hebson; Jacqueline Collins; Connie Trieu; Sushma Boppana; Markus Buchfellner; Cathy Seripin; April Yarbrough; Claudette Poole; Shannon Ross; Scott James; Cecelia Hutto; Suresh Boppana

doi:10.1093/ofid/ofad009

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Variants on Short- and Mid-term Cardiac Outcomes in Multisystem Inflammatory Syndrome in Children

Open Forum Infect Dis. 2023 Jan 11;10(1):ofad009. doi: 10.1093/ofid/ofad009. eCollection 2023 Jan.

Authors

Affiliations

¹ Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
² Division of Pediatric Cardiology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
³ Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
⁴ National Institutes of Health Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁵ Children's of Alabama, Birmingham, Alabama, USA.

Abstract

Cardiac outcomes of 131 children with multisystem inflammatory syndrome (MIS-C) were examined. The majority of the cohort was male (66.4%) and half were Black (49.6%). Cardiac involvement was evident in 25% of the cohort at diagnosis. Favorable short- and mid-term outcomes were documented on follow-up, irrespective of the severe acute respiratory syndrome coronavirus 2 variants causing the infection.

Keywords: MIS-C; SARS-CoV-2; cardiac.

Grants and funding

U01 CA260462/CA/NCI NIH HHS/United States