Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients

Benjamin J Dunmore; Paul D Upton; Kate Auckland; Romit J Samanta; CITIID‐NIHR BioResource COVID‐19 Collaboration; EpiCov Database; Paul A Lyons; Kenneth G C Smith; Stefan Gräf; Charlotte Summers; Nicholas W Morrell

doi:10.1002/pul2.12192

Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients

Pulm Circ. 2023 Jan 1;13(1):e12192. doi: 10.1002/pul2.12192. eCollection 2023 Jan.

Authors

Benjamin J Dunmore^{1

2}, Paul D Upton^{1

2}, Kate Auckland^{1

2}, Romit J Samanta^{1

2

3}; CITIID‐NIHR BioResource COVID‐19 Collaboration; EpiCov Database; Paul A Lyons^{2

4}, Kenneth G C Smith^{2

3

5

4}, Stefan Gräf^{1

2}, Charlotte Summers^{1

2

3}, Nicholas W Morrell^{1

2

3}

Affiliations

¹ Heart and Lung Research Institute University of Cambridge Cambridge UK.
² Department of Medicine University of Cambridge School of Clinical Medicine Cambridge UK.
³ Cambridge University Hospitals and Royal Papworth Hospital NHS Foundation Trust Cambridge UK.
⁴ Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre University of Cambridge Cambridge UK.
⁵ NIHR BioResource for Translational Research Cambridge University Hospitals NHS Foundation Trust Cambridge UK.

Abstract

Similar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID-19) is characterized by the aberrant expression of vascular injury biomarkers. We present the first report that circulating plasma bone morphogenetic proteins (BMPs), BMP9 and pBMP10, involved in vascular protection, are reduced in hospitalized patients with COVID-19.

Keywords: BMPs; endothelial cell dysfunction; viral infections and pathogenesis.

Abstract

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