Visible Light-Mediated Carbamoylation of para-Quinone Methides

J Org Chem. 2023 Mar 3;88(5):2784-2791. doi: 10.1021/acs.joc.2c02394. Epub 2023 Feb 15.

Abstract

We report a photocatalytic approach for the installation of the amide moiety onto para-quinone methides. This transformation features a net reductive approach for the generation of carbamoyl radicals from amide-substituted Hantzsch ester derivatives under transition metal-free conditions. This protocol exhibits wide scope and allows access to diarylacetamides employing a C-C bond formation approach.