The efficacy of sequential MMF-rescue-regimen to eradicate inhibitors for refractory severe hemophilia A inhibitor children in China

Zhengping Li; Zekun Li; Jie Sun; Xiaoling Cheng; Guoqing Liu; Wanru Yao; Kun Huang; Di Ai; Zhenping Chen; Gang Li; Yingzi Zhen; Man-Chiu Poon; Runhui Wu

doi:10.1016/j.thromres.2023.02.011

The efficacy of sequential MMF-rescue-regimen to eradicate inhibitors for refractory severe hemophilia A inhibitor children in China

Thromb Res. 2023 Apr:224:60-64. doi: 10.1016/j.thromres.2023.02.011. Epub 2023 Feb 24.

Authors

Zhengping Li¹, Zekun Li¹, Jie Sun¹, Xiaoling Cheng², Guoqing Liu³, Wanru Yao³, Kun Huang¹, Di Ai¹, Zhenping Chen⁴, Gang Li⁴, Yingzi Zhen³, Man-Chiu Poon⁵, Runhui Wu⁶

Affiliations

¹ Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology-Oncology, 100045, China; National Key Discipline of Pediatrics (Capital Medical University), 100045, China; Key Laboratory of Major Diseases in Children, Ministry of Education, 100045, China; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China; Hematologic Disease Laboratory, Hematology Center, Beijing Key Laboratory of Pediatric Hematology-Oncology, 100045, China; Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China.
² Department of Pharmacy, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
³ Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology-Oncology, 100045, China; National Key Discipline of Pediatrics (Capital Medical University), 100045, China; Key Laboratory of Major Diseases in Children, Ministry of Education, 100045, China; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China.
⁴ National Key Discipline of Pediatrics (Capital Medical University), 100045, China; Key Laboratory of Major Diseases in Children, Ministry of Education, 100045, China; Hematologic Disease Laboratory, Hematology Center, Beijing Key Laboratory of Pediatric Hematology-Oncology, 100045, China; Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China.
⁵ Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pediatrics, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Oncology, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada. Electronic address: mcpoon@ucalgary.ca.
⁶ Hemophilia Comprehensive Care Center, Hematology Center, Beijing Key Laboratory of Pediatric Hematology-Oncology, 100045, China; National Key Discipline of Pediatrics (Capital Medical University), 100045, China; Key Laboratory of Major Diseases in Children, Ministry of Education, 100045, China; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, China. Electronic address: runhuiwu@hotmail.com.

PMID: 36863259
DOI: 10.1016/j.thromres.2023.02.011

No abstract available

Keywords: Immune tolerance induction; Mycophenolate mofetil; Refractory; Rescue regimen; Severe hemophilia A.

Publication types

Letter

MeSH terms

Child
China
Hemophilia A* / drug therapy
Humans
Immunosuppressive Agents
Kidney Transplantation*
Mycophenolic Acid

Substances

Immunosuppressive Agents
Mycophenolic Acid