Decision-making and frontoparietal resting-state functional connectivity among impulsive-compulsive diagnoses. Insights from a Bayesian approach

J J León; P Fernández-Martin; A González-Rodríguez; R Rodríguez-Herrera; J García-Pinteño; C Pérez-Fernández; A Sánchez-Kuhn; L Amaya-Pascasio; M Soto-Ontoso; P Martínez-Sánchez; F Sánchez-Santed; P Flores

doi:10.1016/j.addbeh.2023.107683

Decision-making and frontoparietal resting-state functional connectivity among impulsive-compulsive diagnoses. Insights from a Bayesian approach

Addict Behav. 2023 Aug:143:107683. doi: 10.1016/j.addbeh.2023.107683. Epub 2023 Mar 11.

Authors

Affiliations

¹ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: jld774@ual.es.
² Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: pfm246@ual.es.
³ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: agr609@ual.es.
⁴ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: mrh586@ual.es.
⁵ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: jgp381@ual.es.
⁶ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: cpf603@ual.es.
⁷ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: ask940@ual.es.
⁸ Department of Neurology and Stroke Centre. Torrecárdenas University Hospital, Spain. Electronic address: laura.amaya.pascasio.sspa@juntadeandalucia.es.
⁹ Mental Health Departament. Torrecárdenas University Hospital, Spain. Electronic address: Miguel.Soto.ontoso.sspa@juntadeandalucia.es.
¹⁰ Department of Neurology and Stroke Centre. Torrecárdenas University Hospital, Spain. Electronic address: patrinda@ual.es.
¹¹ Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: fsanchez@ual.es.
¹² Department of Psychology, Faculty of Psychology, University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain; Health Research Centre (CEINSA), University of Almeria, Carretera de Sacramento S/N, 04120, La Cañada de San Urbano, Almeria, Spain. Electronic address: pflores@ual.es.

PMID: 36963236
DOI: 10.1016/j.addbeh.2023.107683

Abstract

The Iowa Gambling Task (IGT) is one of the most widely used paradigms for assessing decision-making. An impairment in this process may be linked to several psychopathological disorders, such as obsessive-compulsive disorder (OCD), substance abuse disorder (SUD) or attention-deficit/hyperactivity disorder (ADHD), which could make it a good candidate for being consider a transdiagnostic domain. Resting-state functional connectivity (rsFC) has been proposed as a promising biomarker of decision-making. In this study, we aimed to identify idiosyncratic decision-making profiles among healthy people and impulsive-compulsive spectrum patients during the IGT, and to investigate the role of frontoparietal network (FPN) rsFC as a possible biomarker of different decision-making patterns. Using functional near-infrared spectroscopy (fNIRS), rsFC of 114 adults (34 controls; 25 OCD; 41 SUD; 14 ADHD) was obtained. Then, they completed the IGT. Hybrid clustering methods based on individual deck choices yielded three decision-makers subgroups. Cluster 1 (n = 27) showed a long-term advantageous strategy. Cluster 2 (n = 25) presented a maladaptive decision-making strategy. Cluster 3 (n = 62) did not develop a preference for any deck during the task. Interestingly, the proportion of participants in each cluster was not different between diagnostic groups. A Bayesian general linear model showed no credible differences in the IGT performance between diagnostic groups nor credible evidence to support the role of FPN rsFC as a biomarker of decision-making under the IGT context. This study highlights the importance of exploring in depth the behavioral and neurophysiological variables that may drive decision-making in clinical and healthy populations.

Keywords: Bayesian general linear model; Decision-making; IGT; Resting-state functional connectivity; fNIRS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bayes Theorem
Biomarkers
Decision Making / physiology
Gambling*
Humans
Neuropsychological Tests
Substance-Related Disorders*

Substances

Biomarkers