Cutaneous vascular tumors: an updated review

Jasmine S Saleh; Carli P Whittington; Scott C Bresler; Rajiv M Patel

doi:10.1016/j.humpath.2023.04.004

Cutaneous vascular tumors: an updated review

Hum Pathol. 2023 Oct:140:53-65. doi: 10.1016/j.humpath.2023.04.004. Epub 2023 Apr 12.

Authors

Jasmine S Saleh¹, Carli P Whittington¹, Scott C Bresler², Rajiv M Patel³

Affiliations

¹ Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
² Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
³ Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Cutaneous Pathology, WCP Laboratories, Inc., Maryland Heights, MO 63043, USA. Electronic address: rajivpat@med.umich.edu.

PMID: 37059271
DOI: 10.1016/j.humpath.2023.04.004

Abstract

Cutaneous vascular tumors constitute a heterogeneous group of entities that share overlapping morphologic and immunohistochemical features, which can be diagnostically challenging for pathologists and dermatopathologists. Our understanding and knowledge of vascular neoplasms have improved over time, resulting in both a refinement of their classification by the International Society for the Study of Vascular Anomalies (ISSVA) and an improvement in the accurate diagnosis and clinical management of vascular neoplasms. This review article aims to summarize the updated clinical, histopathological, and immunohistochemical characteristics of cutaneous vascular tumors, as well as to highlight their associated genetic mutations. Such entities include infantile hemangioma, congenital hemangioma, tufted angioma, spindle cell hemangioma, epithelioid hemangioma, pyogenic granuloma, Kaposiform hemangioendothelioma, retiform hemangioendothelioma, pseudomyogenic hemangioendothelioma, Kaposi sarcoma, angiosarcoma, and epithelioid hemangioendothelioma.

Keywords: Cutaneous vascular tumors; Genetic mutations; Histopathology; ISSVA; Immunohistochemistry; International Society for the Study of Vascular Anomalies.