Impact of Percutaneous Intervention Compared to Pharmaceutical Therapy on Complex Arrhythmias in Patients With Chronic Total Coronary Occlusion. Rationale and Design of the CTO-ARRHYTHMIA Study

Cardiovasc Revasc Med. 2023 Sep:54:69-72. doi: 10.1016/j.carrev.2023.04.001. Epub 2023 Apr 10.

Abstract

Chronic total coronary occlusions (CTO) occur in up to 50 % of patients with coronary artery disease by angiography. In CTO-patients, clinically significant arrhythmia is potentially important and insufficiently investigated. Therefore, the purpose of the CTO-ARRHYTHMIA study was to investigate the incidence of loop recorder detected clinically significant arrhythmias and the effect on arrhythmias of revascularization by CTO-PCI. The study is an independent sub-study of the NOrdic-Baltic Randomized Registry Study for Evaluation of PCI in Chronic Total Coronary Occlusion (NOBLE-CTO); ClinicalTrials.gov Identifier NCT03392415. NOBLE-CTO prospectively collects procedural data, quality of life measures, echocardiographic and cardiac MRI findings before and after treatment as well as clinical outcomes in all CTO patients that may be treated by PCI.

Keywords: Arrhythmias; CTO; Chronic total occlusion; Ventricular tachycardia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Arrhythmias, Cardiac / diagnosis
  • Arrhythmias, Cardiac / epidemiology
  • Arrhythmias, Cardiac / therapy
  • Chronic Disease
  • Coronary Angiography
  • Coronary Occlusion* / diagnostic imaging
  • Coronary Occlusion* / epidemiology
  • Coronary Occlusion* / therapy
  • Humans
  • Percutaneous Coronary Intervention*
  • Pharmaceutical Preparations
  • Quality of Life
  • Registries
  • Risk Factors
  • Treatment Outcome

Substances

  • Pharmaceutical Preparations

Associated data

  • ClinicalTrials.gov/NCT03392415