Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era

Hisashi Ishida; Hiroyuki Shimada; Akihiko Tanizawa; Yutaka Shimazu; Takayoshi Tachibana; Noriko Doki; Takahide Ara; Yayoi Matsuo; Miho Nara; Tomomi Toubai; Kazuko Ino; Hirohisa Nakamae; Keisuke Kato; Koji Kato; Atsushi Sato; Moeko Hino; Kimikazu Matsumoto; Yoshiko Atsuta; Masahiro Yasui; Tokiko Nagamura-Inoue

doi:10.1002/ajh.26959

Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era

Am J Hematol. 2023 Aug;98(8):E200-E203. doi: 10.1002/ajh.26959. Epub 2023 May 12.

Authors

Hisashi Ishida¹, Hiroyuki Shimada², Akihiko Tanizawa³, Yutaka Shimazu⁴, Takayoshi Tachibana⁵, Noriko Doki⁶, Takahide Ara⁷, Yayoi Matsuo⁸, Miho Nara⁹, Tomomi Toubai¹⁰, Kazuko Ino¹¹, Hirohisa Nakamae¹², Keisuke Kato¹³, Koji Kato¹⁴, Atsushi Sato¹⁵, Moeko Hino¹⁶, Kimikazu Matsumoto¹⁷, Yoshiko Atsuta^{18

19}, Masahiro Yasui²⁰, Tokiko Nagamura-Inoue²¹

Affiliations

¹ Department of Pediatrics, Okayama University Hospital, Okayama, Japan.
² Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
³ Department of Pediatrics, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan.
⁴ Department of Hematology Kyoto University Hospital, Kyoto, Japan.
⁵ Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
⁶ Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
⁷ Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
⁸ Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
⁹ Division of Blood Transfusion, Akita University Hospital, Akita, Japan.
¹⁰ Department of Hematology and Cell Therapy, Yamagata University Hospital, Yamagata, Japan.
¹¹ Department of Hematology and Oncology, Mie University Hospital, Tsu, Japan.
¹² Department of Hematology, Osaka Metropolitan University Hospital, Osaka, Japan.
¹³ Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan.
¹⁴ Central Japan Cord Blood Bank, Seto, Japan.
¹⁵ Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.
¹⁶ Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
¹⁷ Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
¹⁸ Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.
¹⁹ Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan.
²⁰ Department of Pediatric Hematology/Oncology, Kitakyushu City Yahata Hospital, Kitakyushu, Japan.
²¹ Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

PMID: 37170859
DOI: 10.1002/ajh.26959

Abstract

The analysis of 165 children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia showed disease status at hematopoietic stem cell transplantation was a strong prognostic factor and clearly separated the patient outcomes.

Publication types

Letter

MeSH terms

Adolescent
Child
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / therapy
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use
Retrospective Studies
Transplantation, Homologous
Tyrosine Kinase Inhibitors
Young Adult

Substances

Tyrosine Kinase Inhibitors
Protein Kinase Inhibitors