What is malignant hyperthermia susceptibility?

Abstract

The molecular mechanisms of susceptibility to malignant hyperthermia are complex. The malignant hyperthermia susceptibility phenotype should be reserved for patients who have a personal or family history consistent with malignant hyperthermia under anaesthesia and are subsequently demonstrated through diagnostic testing to be at risk.

Keywords: caffeine; calcium; malignant hyperthermia; pharmacogenetic; phenotype; skeletal muscle; susceptibility; volatile anaesthetic.