Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal

Sibongiseni Malinga; Aabida Khan; Moherndran Archary

doi:10.4102/sajhivmed.v24i1.1458

Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal

South Afr J HIV Med. 2023 May 23;24(1):1458. doi: 10.4102/sajhivmed.v24i1.1458. eCollection 2023.

Authors

Sibongiseni Malinga¹, Aabida Khan^{2

3}, Moherndran Archary^{1

4}

Affiliations

¹ Department of Paediatrics, King Edward VIII Hospital, Durban, South Africa.
² Department of Virology, Inkosi Albert Luthuli Central Hospital, National Health Laboratory Service (NHLS), Durban, South Africa.
³ School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
⁴ Department of Paediatrics and Child Health, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Abstract

We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.

Keywords: DTG; HIV; adolescence; dolutegravir; paediatrics; resistance.

Publication types

Case Reports