Connectivity and Excitability Shape Seizure Circuits

Anastasia Brodovskaya; Jaideep Kapur

doi:10.1177/15357597221136961

Connectivity and Excitability Shape Seizure Circuits

Epilepsy Curr. 2022 Nov 28;23(3):169-174. doi: 10.1177/15357597221136961. eCollection 2023 May-Jun.

Authors

Anastasia Brodovskaya¹, Jaideep Kapur^{1

2}

Affiliations

¹ Department of Neurology, University of Virginia, Charlottesville, VA, USA.
² UVA Brain Institute, University of Virginia, Charlottesville, VA, USA.

Abstract

Mapping neuronal circuits that generate focal to bilateral tonic-clonic seizures is essential for understanding general principles of seizure propagation and modifying the risk of death and injury due to bilateral motor seizures. We used novel techniques developed over the past decade to study these circuits. We propose the general hypothesis that at the mesoscale, seizures follow anatomical projections of the seizure focus, preferentially activating more excitable neurons.

Keywords: anatomic connectivity; basal ganglia; bilateral synchrony; circuit mapping; generalized tonic–clonic seizures; motor cortex; neuronal excitability; superficial cortical layers 2/3.

Publication types

Review