Allergic Acute Coronary Syndrome-Kounis Syndrome

Leen Alblaihed; Maite Anna Huis In 't Veld

doi:10.1016/j.iac.2022.10.010

Allergic Acute Coronary Syndrome-Kounis Syndrome

Immunol Allergy Clin North Am. 2023 Aug;43(3):503-512. doi: 10.1016/j.iac.2022.10.010.

Authors

Leen Alblaihed¹, Maite Anna Huis In 't Veld²

Affiliations

¹ Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA. Electronic address: https://twitter.com/LeenAlblaihed.
² Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA; Department of Emergency Medicine, Diakonessenhuis Utrecht, Bosboomlaan 1, 3582 KE Utrecht, the Netherlands. Electronic address: m.huisintveld@etz.nl.

PMID: 37394256
DOI: 10.1016/j.iac.2022.10.010

Abstract

Acute coronary syndrome (ACS) in the setting of an allergic/immunologic reaction is known as Kounis syndrome. It is an underdiagnosed and underrecognized disease entity. One must keep a high index of suspicions when managing a patient presenting with cardiac as well as allergic symptoms. There are 3 main variants to the syndrome. Treating the allergic reaction may alleviate the pain; however, ACS guidelines should be followed if cardiac ischemia is present.

Keywords: Acute coronary syndrome; Allergic reaction; Kounis syndrome; Vasospastic angina.

Publication types

Review

MeSH terms

Acute Coronary Syndrome* / diagnosis
Acute Coronary Syndrome* / etiology
Acute Coronary Syndrome* / therapy
Humans
Hypersensitivity*
Kounis Syndrome* / diagnosis
Kounis Syndrome* / etiology
Kounis Syndrome* / therapy