Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system

Aysenur Karaduman; Elif Tugce Karoglu-Eravsar; Utku Kaya; Alaz Aydin; Michelle M Adams; Hulusi Kafaligonul

doi:10.1016/j.neurobiolaging.2023.06.005

Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system

Neurobiol Aging. 2023 Oct:130:12-21. doi: 10.1016/j.neurobiolaging.2023.06.005. Epub 2023 Jun 10.

Authors

Aysenur Karaduman¹, Elif Tugce Karoglu-Eravsar², Utku Kaya³, Alaz Aydin⁴, Michelle M Adams⁵, Hulusi Kafaligonul⁶

Affiliations

¹ National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye; Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye.
² Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Türkiye; Department of Psychology, Selcuk University, Konya, Türkiye.
³ Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
⁴ National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye; Department of Cognitive Science, Informatics Institute, Middle East Technical University, Ankara, Türkiye.
⁵ National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye; Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Türkiye; Department of Psychology, Bilkent University, Ankara, Türkiye.
⁶ National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye; Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Türkiye. Electronic address: hulusi@bilkent.edu.tr.

PMID: 37419077
DOI: 10.1016/j.neurobiolaging.2023.06.005

Abstract

Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (ache^sb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.

Keywords: Acetylcholinesterase; Aging; Motion detection; Second-order motion; Zebrafish.