LncRNA PVT1: as a therapeutic target for breast cancer

Kamilya Jamel Baljon; Pushpamala Ramaiah; Ebraheem Abdu Musad Saleh; F Al-Dolaimy; Farqad Hassan Al-Dami; Kumaraswamy Gandla; Adnan Taan Alkhafaji; Ahmed Hussien R Abbas; Ali Hashiem Alsaalamy; Yashwant Singh Bisht

doi:10.1016/j.prp.2023.154675

LncRNA PVT1: as a therapeutic target for breast cancer

Pathol Res Pract. 2023 Aug:248:154675. doi: 10.1016/j.prp.2023.154675. Epub 2023 Jul 6.

Affiliations

¹ Faculty of Nursing, Umm al, Qura University,Makkah, Saudi Arabia.
² Faculty of Nursing,Umm al, Qura University, Makkah, Saudi Arabia.
³ Department of Chemistry,College of Arts and Science, Prince Sattam Bin Abdulaziz University, Wadi Al-Dawasir 11991, Saudi Arabia. Electronic address: e.saleh@psau.edu.sa.
⁴ Al-Zahraa University for Women, Karbala, Iraq.
⁵ Department of Medical Laboratory Techniques, Altoosi University College, Najaf, Iraq.
⁶ Department of Pharmaceutical Analysis, Chaitanya Deemed to be University, Hanamkonda, India. Electronic address: Kumaraswamygandla94@gmail.com.
⁷ Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq.
⁸ College of technical engineering, the Islamic University, Najaf, Iraq; College of technical engineering, the Islamic University of Al Diwaniyah, Iraq; College of technical engineering, the Islamic University of Babylon, Iraq.
⁹ College of technical engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.
¹⁰ Uttaranchal Institute of Technology, Uttaranchal University, Dehradun 248007, India.

PMID: 37531833
DOI: 10.1016/j.prp.2023.154675

Abstract

A significant number of women are identified with breast cancer (BC) every year, making it among the most prevalent malignancies and one of the leading causes of mortality globally. Despite significant progress in understanding BC pathogenesis and treatment options, there is still a need to identify new therapeutic targets and develop more effective treatments. LncRNAs have been discovered as biomarkers and a promising target for various cancers, including BC. PVT1 is a particular one of these lncRNAs, and research has indicated that it has a significant impact on the appearance and progression of BC.PVT1 is an attractive therapeutic target for BC due to its role in promoting cancer cell growth, metastasis and invasion. In addition to its potential as a treatment strategy, PVT1 may also have diagnostic value in BC. In this article, we will discuss targeting PVT1 as a treatment strategy for BC.

Keywords: Breast cancer; Cancer cells; Effective micro-RNAs; LncRNA-PVT1.

Publication types

Review

MeSH terms

Breast Neoplasms* / genetics
Breast Neoplasms* / pathology
Female
Gene Expression Regulation, Neoplastic / genetics
Humans
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding