Type II innate lymphoid cell (ILC2) is a newly identified innate immunological cell that belongs to the lymphocyte lineage in cell morphology, resides in the body's mucosal tissues, and has the dual functions of innate and adaptive immunity to promote tissue remodeling and repair after injury. Additionally, it is involved in the occurrence and development of a variety of liver diseases and plays an important role in maintaining the immunological homeostasis of the liver region. This article reviews the differentiation, development, and biological functions of ILC2, with particular attention to the research progress in liver diseases.
Ⅱ型固有淋巴细胞(ILC2)是一种近几年被发现的在细胞形态上属于淋巴细胞谱系的新型固有免疫细胞，常驻于机体黏膜组织中，兼备固有免疫和适应性免疫的双重功能，可促进损伤后的组织重塑和修复。ILC2参与了多种肝脏疾病的发生和发展，在维护肝脏区域免疫稳态中发挥了重要作用。现综述ILC2的分化、发育及其生物学功能，并特别关注ILC2在肝脏疾病中的作用研究进展。.
Keywords: Innate immunity; Liver diseases; Progress; Type II innate lymphocytes.